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Related Experiment Video

Updated: Jun 5, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Oxidative stress and skeletal muscle dysfunction with aging.

Wataru Aoi¹, Kunihiro Sakuma

¹Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan. waoi@kpu.ac.jp

Current Aging Science

|January 18, 2011

Summary

Aging increases muscle oxidative stress, damaging tissues and causing muscle dysfunction. Regular exercise and antioxidants can counteract this, improving muscle health.

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Published on: July 5, 2017

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

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Published on: July 22, 2013

Area of Science:

Muscle physiology
Aging research
Oxidative stress biology

Background:

With aging, muscle tissues experience increased reactive oxygen species production, leading to elevated oxidative stress.
Oxidative stress damages cellular components like lipids, proteins, and DNA within muscle.
This cellular damage impacts muscle energy metabolism, protein degradation, and apoptosis, contributing to age-related muscle dysfunction.

Purpose of the Study:

To describe the influence of oxidative stress on age-related muscle dysfunction.
To review countermeasures for mitigating oxidative stress in aging muscle.

Main Methods:

Review of scientific literature on aging, oxidative stress, and muscle physiology.
Analysis of the effects of oxidative stress on cellular processes in muscle.
Evaluation of exercise and nutritional interventions as countermeasures.

Main Results:

Oxidative stress significantly contributes to the loss of muscle mass and metabolic dysfunction associated with aging.
Evidence suggests oxidative stress affects muscle function through transcriptional and post-translational regulation of key proteins.
Regular exercise and antioxidant-rich nutrition can reduce oxidative stress and improve muscle function.

Conclusions:

Oxidative stress is a key factor in age-related muscle dysfunction.
Exercise and proper nutrition are effective strategies to combat muscle aging by reducing oxidative stress.