Patient-ventilator interaction: the last 40 years
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Updated: Jun 5, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
1Division of Trauma and Critical Care, Department of Surgery, University of Cincinnati Medical Center, 231 Albert Sabin Way, ML 0558, Cincinnati OH, USA. richard.branson@uc.edu
Abstract:
Patient-ventilator synchrony is a complex issue affected by ventilator performance, patient characteristics, and the patient-ventilator interface. The history of patient-ventilator interaction includes avoidance of pharmacalogic paralysis, the development of spontaneous breathing systems, microprocessor technology to maximize interaction, and closed-loop control. While most clinicians agree that patient-ventilator synchrony is desirable, there remain no cause-and-effect data that asynchrony is associated with poor outcome.
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