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Related Concept Videos

Bernoulli's Principle01:01

Bernoulli's Principle

Bernoulli's equation incorporates how fluid pressure changes across a static, incompressible fluid by equating the kinetic energy contribution to zero. It is also helpful in analyzing horizontal flows in which the gravitational energy density is constant throughout. The latter equation is so useful that it is called Bernoulli's principle. According to Bernoulli's principle, the fluid pressure drops if the speed increases and vice versa.
Bernoulli's principle has several applications. It is used...
Bernoulli's Equation for Flow Along a Streamline01:30

Bernoulli's Equation for Flow Along a Streamline

Bernoulli's equation relates the energy conservation in a fluid moving along a streamline. The equation applies to incompressible and inviscid fluids under steady flow. For such a flow, Newton's second law is applied to a small fluid element, which experiences forces due to pressure differences, gravity, and velocity variations. The force balance leads to the following form of Bernoulli's equation:
Bernoulli's Equation00:59

Bernoulli's Equation

In the middle of the nineteenth century, it was observed that two trains passing each other at a high relative speed get pulled towards each other. The same occurs when two cars pass each other at a high relative speed. The reason is that the fluid pressure drops in the region where the fluid speeds up. As the air between the trains or the cars increases in speed, its pressure reduces. The pressure on the outer parts of the vehicles is still the atmospheric pressure, while the resultant...
Bernoulli's Equation for Flow Normal to a Streamline01:16

Bernoulli's Equation for Flow Normal to a Streamline

Bernoulli's equation for flow normal to a streamline explains how pressure varies across curved streamlines due to the outward centrifugal forces induced by the fluid's curvature. The pressure is higher on the inner side of the curve, near the center of curvature, and decreases outward to balance these centrifugal forces.
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...
Bernoulli's Equation: Problem Solving01:16

Bernoulli's Equation: Problem Solving

A Venturi meter is essential for measuring fluid flow rates in pipelines. It utilizes the relationship between fluid velocity and pressure described by Bernoulli's equation. When installed in a sewage system, the Venturi meter accurately determines the wastewater flow rate by measuring pressure differences.
The first step is to compute the cross-sectional areas of the pipe and the Venturi throat to analyze the pressure difference indicated by the pressure gauge. Next, the continuity equation is...
Bernoulli's Principle: Applications01:17

Bernoulli's Principle: Applications

There are many devices and situations in which fluid flows at a constant height and so can be analyzed using Bernoulli's principle. These devices include, but are not limited to, entrainment devices and fluid flow measuring devices.
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:

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Related Experiment Video

Updated: Jun 5, 2026

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
07:34

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

Published on: December 30, 2025

The bernard-soulier syndrome.

B A Konkle1

  • 1Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.

Trends in Cardiovascular Medicine
|January 18, 2011
PubMed
Summary

Bernard-Soulier syndrome (BSS) is a rare inherited platelet disorder. It results from a deficient platelet GpIb-V-IX receptor, crucial for blood clotting and platelet structure.

Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Bernard-Soulier syndrome (BSS) is a rare inherited disorder affecting platelet function.
  • It is characterized by the absence or reduced expression of the platelet GpIb-V-IX receptor complex.
  • This receptor is vital for primary hemostasis, mediating platelet adhesion and activation at vascular injury sites.

Purpose of the Study:

  • To elucidate the structure and function of the platelet GpIb-V-IX receptor complex.
  • To understand the genetic basis of Bernard-Soulier syndrome.
  • To advance knowledge of the GpIb-V-IX complex's role in hemostasis.

Main Methods:

  • Analysis of cDNA and genomic structures of GpIb-V-IX complex components.
  • Identification and characterization of mutations responsible for BSS.

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Last Updated: Jun 5, 2026

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  • Investigation of the receptor's link to the platelet cytoskeleton.

    • Main Results:

    • Detailed understanding of the cDNA and genomic structures of the GpIb-V-IX complex members.
    • Identification of specific mutations causing Bernard-Soulier syndrome.
    • Demonstrated the GpIb-V-IX complex's role in maintaining platelet size and structure.

    Conclusions:

    • Elucidation of GpIb-V-IX complex structure and mutations has significantly advanced BSS knowledge.
    • The GpIb-V-IX complex is essential for platelet adhesion, activation, and overall hemostasis.
    • Understanding this complex provides insights into platelet disorders and therapeutic targets.