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Published on: May 19, 2017
The Sarco(endo)plasmic Reticulum Ca(2+)-ATPases in the Cardiovascular System During Growth and Proliferation
Trends in Cardiovascular Medicine
|January 18, 2011
Summary
The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) is vital for cellular calcium regulation. This review explores SERCA isoform diversity and expression changes in cardiac and vascular cells during development and disease.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Science
Background:
- Sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) maintains low cytosolic calcium levels, crucial for cell function.
- Six SERCA isoforms, derived from three genes, have been identified.
- SERCA isoforms are expressed in cardiovascular cells and their levels change during development and disease.
Purpose of the Study:
- To review recent findings on SERCA isoform diversity.
- To discuss the regulation of SERCA isoform expression in cardiac and vascular cells.
Main Methods:
- Review of existing literature on SERCA isoforms.
- Analysis of studies on SERCA expression in cardiovascular contexts.
Main Results:
- Detailed overview of identified SERCA isoforms and their genetic origins.
- Evidence of differential SERCA isoform expression during ontogenic development.
- Demonstration of altered SERCA expression in pathological cardiovascular conditions.
Conclusions:
- SERCA isoform diversity contributes to cellular calcium handling complexity.
- Modulation of SERCA expression is a key feature in cardiovascular cell adaptation and pathology.
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