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Intermediate filaments in DMBA-induced mammary adenocarcinomas in rats
L Peña1, J M Flores, M Castaño
1Department of Animal Pathology II, Veterinary School, Complutense University of Madrid, Spain.
Zentralblatt Fur Veterinarmedizin. Reihe A
|September 1, 1990
Abstract:
Experimental DMBA (7,12-dimethylbenzanthracene)-induced mammary tumours in rats were studied. Microscopic examination revealed a high rate of adenocarcinomas (95.3% in 148 mammary tumours studied). An immunohistochemical study of cytoskeleton intermediate filaments (I.F.) showed cytokeratins in neoplastic epithelial cells; myoepithelial cells expressed cytokeratins, vimentin and desmin. Finally we propose the immunocytochemical localization of desmin as a useful method to recognize myoepithelial proliferation areas in mammary tumours.