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Updated: Jun 5, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity
David R Gibb1, Sheinei J Saleem, Natalia S Chaimowitz
1Department of Microbiology and Immunology, Virginia Commonwealth University, School of Medicine, P.O. Box 980678, Richmond, VA 23298, USA.
Abstract:
Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses, including activation and differentiation. A member of the disintegrin and metalloproteinase family, ADAM10, has emerged as a prominent regulator of numerous receptors and ligands, including Notch and CD23. Here, we review studies resulting from the recent generation of ADAM10 conditional knockout mice which revealed a critical role for ADAM10 in Notch-dependent lymphocyte development. Additionally, we discuss results of numerous in vitro and ex vivo studies indicating that ADAM10 regulates the production of multiple secreted factors that contribute to autoimmune reactions.
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