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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
Efficient synthesis of new tetradentate ligands with potential applications for 64Cu PET-imaging
Ewen Bodio1, Karine Julienne, Sébastien G Gouin
1CNRS, UMR 6230, Université de Nantes, Chimie et Interdisciplinarité: Synthèse Analyse Modélisation, UFR Sciences et Techniques, Nantes, France.
Abstract:
We wish to report the synthesis of new tetradentate ligands in less than 3h in good to excellent yields from a commercially available compound using microwave-assisted technology. First tests of complexation showed a high ability of these ligands to chelate (64)Cu(II) in very diluted medium. These new systems have the potential to be used for nuclear medicine and particularly for PET-imaging.

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