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Related Experiment Videos

Second trimester pregnancy termination using extra-amniotic ethacridine lactate.

R K Bhathena1, N K Sheriar, V R Walvekar

  • 1Wadia Maternity Hospital, Bombay, India.

British Journal of Obstetrics and Gynaecology
|November 1, 1990
PubMed
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Extra-amniotic ethacridine lactate is effective for second trimester abortion. Supplementing with prostaglandin F2 alpha significantly reduces the time to abortion with minimal complications.

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Health
  • Pharmacology

Background:

  • Second trimester pregnancy termination requires effective and safe methods.
  • Extra-amniotic ethacridine lactate has been used for induction of labor and abortion.
  • Investigating its efficacy and safety in second trimester termination is crucial.

Purpose of the Study:

  • To evaluate the effectiveness of extra-amniotic ethacridine lactate for second trimester pregnancy termination.
  • To assess the complication rates associated with this method.
  • To compare the efficacy of ethacridine lactate alone versus combined with prostaglandin F2 alpha.

Main Methods:

  • A retrospective study involving 315 women undergoing second trimester termination.
  • Two groups: extra-amniotic ethacridine lactate alone (Group 1, n=207) or supplemented with extra-amniotic 15-methyl prostaglandin F2 alpha (Group 2, n=108).
Keywords:
Abortion, Drug Induced--complicationsAbortion, InducedAsiaBiologyClinical ResearchComparative StudiesContraceptionContraceptive UsageDemographic FactorsDeveloping CountriesEndocrine SystemFamily PlanningFertilityFertility Control, PostconceptionFertility MeasurementsIndiaMethod AcceptabilityParityPhysiologyPopulationPopulation DynamicsPregnancyPregnancy, Second TrimesterProstaglandinsReproductionResearch MethodologySouthern AsiaStudiesTime Factors

Related Experiment Videos

  • Outcomes measured included abortion success, induction-abortion interval, and complications like hemorrhage, infection, and uterine injury.

    • Main Results:

    • High success rates were observed: 92% in Group 1 and 98% in Group 2.
    • The median induction-abortion interval was significantly shorter in Group 2 (19 hours) compared to Group 1 (35 hours).
    • Overall complication rate was less than 10%, including unplanned uterine evacuation (6%), hemorrhage (1%), and pelvic infection (4%).

    Conclusions:

    • Extra-amniotic ethacridine lactate is an effective and safe method for second trimester legal abortion.
    • Supplementation with prostaglandin F2 alpha can significantly reduce the induction-abortion interval.
    • This combined approach offers an improved option for second trimester pregnancy termination.