Myeloid derived suppressor cells in human diseases
Tim F Greten1, Michael P Manns, Firouzeh Korangy
1National Institutes of Health, National Cancer Institute, Medical Oncology Branch, 9000 Rockville Pike, Bethesda MD 20892, USA. tim.greten@nih.gov
International Immunopharmacology
|January 18, 2011
Summary
Myeloid-derived suppressor cells (MDSC) are key immune suppressors in humans. This review details their subtypes, markers, and targeted therapies like all-trans-retinoic acid and sunitinib for cancer treatment.
Area of Science:
- Immunology
- Oncology
Background:
- Myeloid-derived suppressor cells (MDSC) are potent immune suppressors in mice, but human MDSC data are limited.
- Human MDSC identification is complex due to varied markers across studies.
- Human MDSC are CD11b+, CD33+, HLA-DR(neg/low) and classified into granulocytic (CD14⁻) and monocytic (CD14+) subtypes.
Purpose of the Study:
- To comprehensively review recent literature on human MDSC.
- To clarify human MDSC subtypes, markers, and functions.
- To summarize therapeutic strategies targeting human MDSC in cancer.
Main Methods:
- Literature review of recent studies on human MDSC.
- Analysis of markers used for human MDSC identification and classification.
- Summary of functional assays and therapeutic interventions.
Main Results:
- Human MDSC subtypes (granulocytic and monocytic) exhibit immune suppressive functions.
- Specific markers like Interleukin 4Rα, VEGFR, CD15, and CD66b aid in MDSC identification.
- Immune suppression is linked to arginase 1, iNOS activity, and ROS production.
- All-trans-retinoic acid and sunitinib show potential in modulating human MDSC function.
Conclusions:
- Human MDSC are critical regulators of the immune response in cancer.
- Targeting MDSC offers a promising therapeutic avenue for cancer treatment.
- Further research is needed to standardize human MDSC identification and therapeutic strategies.
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