[Obesity and female reproduction]
J Sarfati1, J Young, S Christin-Maitre
1Service d'Endocrinologie et des Maladies de la Reproduction, Centre Hospitalier Universitaire de Bicêtre - APHP, 78 rue du Général-Leclerc 94275 Le Kremlin-Bicêtre, France. sarfati_julie@yahoo.fr
Annales D'Endocrinologie
|January 18, 2011
Summary
Maternal obesity negatively impacts female fertility and offspring health. Studies show obesity affects oocytes and embryos, leading to lasting metabolic issues in pups, highlighting the need for preconception weight management.
Area of Science:
- Reproductive biology
- Endocrinology
- Developmental biology
Background:
- Obesity is linked to female infertility, affecting both natural and assisted conception.
- This infertility risk in obese women extends beyond ovulation issues.
- Potential mechanisms involve endometrial and oocyte factors.
Purpose of the Study:
- To investigate the effects of maternal obesity on oocyte quality and early embryonic development.
- To examine the long-term health consequences for offspring born to obese mothers.
Main Methods:
- Utilized a mouse model of maternal obesity.
- Analyzed oocyte mitochondria and reactive oxygen species (ROS) generation.
- Assessed embryonic development, fetal size, and pup health post-weaning.
Main Results:
- Maternal obesity altered oocyte mitochondria and increased ROS in a mouse model.
- Obese mice had decreased embryonic IGF-IR staining and smaller fetuses/pups.
- Offspring from obese mothers showed early signs of metabolic syndrome by 13 weeks.
Conclusions:
- Maternal obesity adversely affects oocytes and preimplantation embryos.
- These effects can lead to lasting health problems in offspring.
- Optimal maternal weight and nutrition before conception are crucial for reproductive success and offspring health.
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