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Updated: Jun 5, 2026

An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
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[Fibrin sealant significantly decrease postoperative drainage in breast reconstruction by deep inferior epigastric

J-L Heusse1, M Hivelin, C Lepage

  • 1Service de chirurgie plastique, hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France. jlheusse@yahoo.fr

Annales De Chirurgie Plastique Et Esthetique
|January 18, 2011
PubMed
Summary

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Fibrin sealant significantly reduced post-operative drainage and hospital stay in patients undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction. This method offers a promising approach to improve patient recovery after DIEP flap surgery.

Area of Science:

  • Plastic Surgery
  • Microsurgery
  • Surgical Innovation

Context:

  • Post-operative serosanguinous drainage is a primary concern in deep inferior epigastric perforator (DIEP) flap breast reconstruction.
  • Minimizing drainage and shortening patient discharge time are critical for improving outcomes.
  • Fibrin sealant has emerged as a potential adjunct to manage surgical bleeding and fluid collection.

Purpose:

  • To evaluate the efficacy of sprayed fibrin sealant in reducing post-operative drainage and length of stay in secondary breast reconstruction using DIEP flaps.
  • To assess the safety and impact of fibrin sealant application on patient recovery metrics.

Summary:

  • A comparative study involving 21 patients undergoing secondary breast reconstruction with DIEP flaps was conducted.

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  • Group 1 (n=9) received standard drain placement, while Group 2 (n=12) had fibrin sealant applied to the DIEP flaps and thoracic areas before drain insertion.
  • Fibrin sealant application resulted in significantly lower drained volumes and earlier drain removal from the thoracic region, leading to a reduced overall length of hospital stay.

    • Impact:

    • Fibrin sealant significantly decreased post-operative drainage volume and duration in DIEP flap breast reconstruction.
    • The use of fibrin sealant led to a statistically significant reduction in the length of hospital stay.
    • This study provides valuable clinical data on the benefits of fibrin sealant in optimizing recovery after complex breast reconstruction procedures.