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Updated: Jun 5, 2026
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
Published on: May 15, 2019
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation
Mar Cuadrado-Tejedor1, Ana Ricobaraza, Joaquín Del Río
1Division of Neurosciences, CIMA, University of Navarra, Avenida Pio XII 55, Pamplona, Spain. mcuadrado@unav.es
Abstract:
This study was undertaken to know whether cognition deficits produced by chronic mild stress (CMS) were associated with pathological markers of Alzheimer's disease (AD). The results show that the impairment in the Morris water maze test induced by CMS correlated with an increase in CDK5-dependent phospho-tau levels and with an increase in APP processing. Mice exposed to CMS may then constitute a non-transgenic model for sporadic forms of AD.
