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Updated: Feb 9, 2026

An Aptamer-based Sensor for Unchelated GadoliniumIII
Published on: January 9, 2017
A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold
Masayori Hagimori1, Naoko Mizuyama, Yasuchika Yamaguchi
1Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan.
Abstract:
The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn(2+) based on pyridine-pyridone skeleton is reported. We observed a clear chelation enhanced fluorescence effect of 3 in the presence of Zn(2+). Other fluorescent properties of 3 are discussed.
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