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Inducing Apical Periodontitis in Mice
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An animal model to study regenerative endodontics.

Mahmoud Torabinejad1, Robert Corr, Matthew Buhrley

  • 1Department of Endodontics, Loma Linda University, Loma Linda, CA, USA. mtorabinejad@llu.edu

Journal of Endodontics
|January 18, 2011
PubMed
Summary

Ferret cuspid teeth show root development similar to humans, making them a viable model for regenerative endodontics research. This study establishes optimal timing for experiments using these teeth.

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Area of Science:

  • Veterinary Dentistry
  • Regenerative Endodontics
  • Animal Models

Background:

  • Evidence suggests pulp regeneration and root development are possible in teeth with necrotic pulps and open apices.
  • Further research using animal models is needed to investigate regenerative endodontics.
  • Ferret cuspid teeth were evaluated as a potential model for these investigations.

Purpose of the Study:

  • To investigate ferret cuspid teeth as a model for regenerative endodontics research.
  • To determine the suitability of ferret teeth for studying factors influencing pulp regeneration and root development.

Main Methods:

  • Six young male ferrets (36-133 days old) were used.
  • Teeth and surrounding tissues were collected, processed, and sectioned.

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  • Hematoxylin-eosin staining was employed to assess apical closure stages.

    • Main Results:

    • Permanent ferret cuspid teeth erupted around 50 days post-birth.
    • Apical foramen closure initiated between 90-110 days.
    • Complete apical closure was observed by 133 days of age.

    Conclusions:

    • Ferret cuspid teeth serve as a suitable animal model for regenerative endodontics research.
    • Experiments should ideally be conducted when ferrets are 50-90 days old for optimal investigation of regenerative processes.