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Related Concept Videos

Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

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Related Experiment Video

Updated: Jun 5, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein Barr virus hepatitis.

Diamantis P Kofteridis1, Mairi Koulentaki, Antonios Valachis

  • 1Department of Internal Medicine-Infectious Disease Unit, University Hospital of Heraklion, Crete, Greece. kofterid@med.uoc.gr

European Journal of Internal Medicine
|January 18, 2011
PubMed
Summary
This summary is machine-generated.

Epstein-Barr Virus (EBV) infection can cause mild hepatitis. Liver function tests normalize within weeks, with most cases showing anicteric cholestatic liver disease and full recovery.

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Epstein-Barr Virus (EBV) establishes lifelong infections, often asymptomatic or causing infectious mononucleosis.
  • Hepatocellular damage is common in EBV infection, but jaundice is rare, with complete recovery typical.

Purpose of the Study:

  • To describe the clinical characteristics of acute EBV infection.
  • To analyze changes in liver function tests during infectious mononucleosis.

Main Methods:

  • Retrospective study of immunocompetent patients with hepatic dysfunction due to acute EBV infection.
  • Inclusion of 41 patients over a 6-year period at the University Hospital of Heraklion.

Main Results:

  • Elevated aspartate-aminotransferase (AST) and alanine-aminotransferase (ALT) by 5-fold, normalizing within 20 days.
  • Increased alkaline-phosphatase (ALP), γ-glutamyltransferase (γ-GT), and bilirubin, normalizing in 20-30 days.
  • Anicteric cholestatic liver disease observed in 59% of patients; jaundice in only 6%.

Conclusions:

  • Acute EBV infection causes mild, self-limited hepatitis.
  • The hepatitis predominantly features cholestatic patterns.
  • Liver involvement in EBV infection typically resolves completely.