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mirMachine: A One-Stop Shop for Plant miRNA Annotation
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MicroRNAs sculpt gene expression in embryonic development: new insights from plants

Ariel A Bazzini1, Antonio J Giraldez

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.

Developmental Cell
|January 18, 2011
PubMed

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...