Related Experiment Video
Updated: Jun 5, 2026

08:42
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
Rumination as a transdiagnostic factor in depression and anxiety
Katie A McLaughlin1, Susan Nolen-Hoeksema
1Department of Health Care Policy, Harvard Medical School, 180A Longwood Avenue, Boston, MA 02115, USA. katie_mclaughlin@hms.harvard.edu
Behaviour Research and Therapy
|January 18, 2011
Summary
Rumination fully explains the link between depression and anxiety symptoms in adolescents and adults. Targeting rumination may help treat co-occurring emotional disorders.
Area of Science:
- Psychology
- Psychiatry
- Clinical Psychology
Background:
- High comorbidity rates in mental disorders necessitate identifying transdiagnostic factors.
- Rumination is implicated in depression and anxiety, but its role in their co-occurrence is unclear.
Purpose of the Study:
- To investigate rumination as a transdiagnostic factor for depression and anxiety.
- To examine rumination's role in concurrent and prospective associations between depression and anxiety symptoms.
Main Methods:
- Two longitudinal studies involving adolescents (N=1065) and adults (N=1317).
- Statistical mediation analyses to assess rumination's role.
Main Results:
- Rumination fully mediated the concurrent link between depression and anxiety in adolescents.
- Rumination partially mediated this link in adults.
- Rumination fully mediated prospective associations between depression and anxiety in both age groups.
Conclusions:
- Rumination is a significant transdiagnostic factor for depression and anxiety.
- Findings support targeting rumination in transdiagnostic treatments for emotional disorders.
Related Concept Videos
Depression: Overview
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Anxiety: Overview
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Social Anxiety Disorder
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Rational Emotive Behavior Therapy
Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert Ellis's...

