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Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Updated: Jun 5, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Published on: November 26, 2018

Polymorphisms in integrin genes and lymphoma risk.

Min Shen1, Tongzhang Zheng, Qing Lan

  • 1Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7240, USA.

Leukemia Research
|January 18, 2011
PubMed
Summary

Genetic variations in integrin genes may influence non-Hodgkin lymphoma (NHL) risk in women. Specific single nucleotide polymorphisms (SNPs) in ADAM19, ICAM3, and PTGDR were linked to altered lymphoma risk, warranting further investigation.

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Area of Science:

  • Immunology
  • Genetics
  • Oncology

Background:

  • Immune deficiency is a significant risk factor for non-Hodgkin lymphoma (NHL).
  • Integrin genes play a crucial role in innate immunity.
  • Genetic variations may influence individual susceptibility to NHL.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in integrin genes and NHL risk.
  • To explore the role of genetic variations in the development of lymphoma in women.

Main Methods:

  • Population-based case-control study of 448 NHL cases and 525 controls.
  • Analysis of 373 tag SNPs across 33 integrin gene regions.
  • Statistical analysis to determine associations between SNPs and NHL risk.

Main Results:

  • The ADAM19 rs11466782 SNP was associated with increased NHL risk (OR, 1.73).
  • ICAM3 rs2304240 (OR, 0.67) and PTGDR rs708486 (OR, 0.75) SNPs were associated with reduced NHL risk.
  • Global associations with NHL risk were observed for ADAM19 and ICAM3 gene regions (P<0.01).

Conclusions:

  • Genetic polymorphisms in integrin genes may contribute to NHL development in women.
  • Findings suggest a potential role for integrin gene variations in lymphoma etiology.
  • Results are exploratory and require replication in independent populations.