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Amoxicillin-induced acute aseptic meningitis

Sergio Prieto-González1, Rosa Escoda, Emmanuel Coloma

  • 1Department of Internal Medicine, Clinical Institute of Medicine and Dermatology, Hospital Clínic, University of Barcelona, Villarroel 170, Barcelona 08036, Spain. sprieto@clinic.ub.es

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|January 18, 2011
PubMed

Insights

Amoxicillin can cause drug-induced aseptic meningitis, a rare but serious condition. Prompt recognition and discontinuation of the antibiotic are crucial for patient recovery.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Aseptic meningitis is a non-infectious inflammation of the meninges.
  • Drug-induced aseptic meningitis is a rare adverse drug reaction.
  • Amoxicillin is a widely prescribed antibiotic.

Observation:

  • A 58-year-old man developed fever and headache after amoxicillin intake.
  • Cerebrospinal fluid analysis revealed lymphocytic pleocytosis.
  • The patient had a history of two similar episodes potentially linked to amoxicillin.

Findings:

  • The patient's symptoms resolved after amoxicillin discontinuation and supportive care.
  • The case meets diagnostic criteria for drug-induced aseptic meningitis.
  • Recurrent episodes suggest a causal relationship with amoxicillin.

Implications:

  • Healthcare providers should consider amoxicillin as a potential cause of aseptic meningitis.
  • Awareness of this adverse drug reaction is important due to amoxicillin's common use.
  • Early diagnosis and antibiotic withdrawal can prevent severe complications.

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