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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

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Articles linked to this work by shared authors, journal, and citation graph.

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Correction: Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study.

PloS one·2018
Same author

Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study.

PloS one·2016
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Is Vitamin D Inadequacy in Early Life an Instance of the "Barker Hypothesis"?

Nutrition today·2016
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Nonenzymatic Glycation and Degree of Mineralization Are Higher in Bone From Fractured Patients With Type 1 Diabetes Mellitus.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2015
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Quantifying the vitamin D economy.

Nutrition reviews·2015
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Screening for vitamin D deficiency: is the goal disease prevention or full nutrient repletion?

Annals of internal medicine·2015

Related Experiment Video

Updated: Jun 5, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D: the iceberg nutrient.

Laura A G Armas1, Robert P Heaney

  • 1Creighton University Osteoporosis Research Center, Omaha, Nebraska, USA.

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|January 18, 2011
PubMed
Summary

Vitamin D is vital for all body cells, not just kidney function. This review explores its impact on cancer, cardiovascular disease, and infections in chronic kidney disease patients.

Area of Science:

  • Endocrinology
  • Nephrology
  • Oncology
  • Cardiology
  • Infectious Diseases

Background:

  • Vitamin D's role extends beyond calcium homeostasis, impacting numerous cellular functions.
  • Chronic kidney disease (CKD) patients often have impaired vitamin D metabolism.
  • Extra-renal vitamin D production persists in CKD patients, with significant health implications.

Purpose of the Study:

  • To review the clinical impact of vitamin D in CKD patients.
  • To examine vitamin D's role in cancer, cardiovascular disease, and infections within the CKD population.

Main Methods:

  • Review of clinical trials and observational studies.
  • Focus on vitamin D's influence on morbidity and mortality in CKD.

Related Experiment Videos

Last Updated: Jun 5, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Main Results:

  • Vitamin D plays a crucial role in managing cancer, cardiovascular disease, and infections in CKD.
  • Understanding extra-renal vitamin D production is key for CKD patient health.

Conclusions:

  • Vitamin D supplementation and management strategies require careful consideration in CKD patients.
  • Further research into vitamin D's multifaceted roles can improve CKD patient outcomes.