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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

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Related Experiment Video

Updated: Jun 5, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Seeking common pathophysiology in asthma, atopy and sinusitis.

Paul C Porter1, Valentine Ongeri, Amber Luong

  • 1Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Trends in Immunology
|January 18, 2011
PubMed
Summary

Fungi may cause asthma and chronic sinusitis by releasing allergenic proteinases that trigger allergic airway inflammation. Identifying these fungal sources is key to improving diagnosis and treatment.

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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Area of Science:

  • Immunology and Respiratory Medicine
  • Environmental Allergy and Microbiology

Background:

  • Asthma and chronic sinusitis are prevalent airway diseases associated with atopy and allergic inflammation.
  • T helper type 2 (Th2) cells and cytokines are implicated in asthma pathogenesis, but environmental triggers are unclear.
  • Environmental proteinases are potent allergens and potential inducers of airway Th2 responses.

Purpose of the Study:

  • To explore the role of fungi as a source of allergenic proteinases.
  • To investigate the link between fungal exposure, allergic airway diseases, and chronic sinusitis.
  • To identify extrinsic factors contributing to allergic airway inflammation.

Main Methods:

  • Review of existing evidence implicating fungi in allergic airway disease.
  • Analysis of the role of fungal proteinases in initiating Th2 responses.
  • Examination of the connection between airway fungal infections and disease development.

Main Results:

  • Fungi are identified as a significant source of allergenic proteinases.
  • Evidence suggests fungi can induce allergic airway inflammation, atopy, and chronic sinusitis.
  • Airway infection by fungi is proposed as a mechanism for disease initiation.

Conclusions:

  • Fungi are implicated as a key environmental factor in the development of asthma, atopy, and chronic sinusitis.
  • Understanding fungal proteinases and their role in airway disease is crucial.
  • Clarifying fungal involvement can lead to improved diagnostic and therapeutic strategies.