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Updated: Jun 5, 2026

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
Immune cytokines and cardiac disease
1Department of Medicine, Cardiology Division, Jewish Hospital of St. Louis at the Washington University Medical Center, St. Louis, MO 63110, USA.
Abstract:
In conditions such as idiopathic dilated congestive cardiomyopathy associated with lymphocytic myocarditis and cardiac allograft rejection, the immune system can reversibly impair cardiac function. Cytokines interleukin-1 and tumor necrosis factor disrupt β-adrenergic signal transduction and agonist stimulation of contractility. Identification of this reversible effect potentially offers a novel pathophysiologic mechanism for producing cardiac injury.
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