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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

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Related Experiment Video

Updated: Jun 5, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
08:00

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Embryonic stem cells as a model for cardiogenesis.

J Robbins1, T Doetschman, W K Jones

  • 1Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

Trends in Cardiovascular Medicine
|January 18, 2011
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells can be genetically modified for disease modeling. In culture, these cells form embryoid bodies, recapitulating early heart development for research.

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In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
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In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

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Last Updated: Jun 5, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
08:00

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

Area of Science:

  • Developmental biology
  • Stem cell research
  • Cardiovascular research

Background:

  • Embryonic stem (ES) cells originate from mouse blastocysts.
  • ES cells maintain pluripotency and proliferative capacity on feeder layers.
  • They are amenable to gene targeting for creating disease models.

Purpose of the Study:

  • To explore the potential of ES cells in developing animal models for human cardiovascular diseases.
  • To investigate the utility of embryoid body (EB) development for studying early cardiogenesis.

Main Methods:

  • Culturing mouse ES cells on fibroblast feeder layers.
  • Inducing differentiation by removing ES cells from feeder layers to form embryoid bodies (EBs).
  • Analyzing EB development using morphologic, biochemical, and molecular genetic techniques.

Main Results:

  • ES cells remain undifferentiated and pluripotent on feeder layers.
  • ES cells are competent for gene targeting via homologous recombination.
  • EB formation leads to differentiation and recapitulation of early cardiogenic events.

Conclusions:

  • ES cells offer potential for creating animal models of human cardiovascular disease.
  • Embryoid body development in vitro serves as a valuable model for studying early cardiac development.