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Updated: Jun 5, 2026

Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse
Published on: December 22, 2020
Connexins and the heart
1Department of Medicine, Cardiology Division, and the Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abstract:
Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development. Recent studies have identified the connexin gene family whose protein products assemble to form gap junction channels. Studies of connexin gene expression and function are providing new insights into the behavior of gap junction channels in the heart.
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