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Updated: Jun 5, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Thromboxane biosynthesis and metabolism in relation to cardiovascular risk factors
C Patrono1, G Davi, G Ciabattoni
1Departments of Pharmacology and Hematology, University of Chieti "G. D'Annunzio" School of Medicine, Chieti Italy.
Abstract:
Enhanced platelet biosynthesis of thromboxane A(2) is associated with several cardiovascular risk factors, as a consequence of a direct effect on platelet biochemistry and/or some form of endothelial dysfunction. Moreover, episodic increases in thromboxane biosynthesis occur in acute coronary and cerebral ischemic syndromes. Thromboxane-dependent platelet activation represents an important mechanism that amplifies the consequences of acute vascular lesions as well as those of longstanding metabolic or hemodynamic disturbances, and results in increased risk of vascular occlusive events.
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