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Related Experiment Video

Updated: Jun 5, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

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Digitalis and baroreflexes in heart failure.

¹Associate Professor of Medicine and Director of the Cardiovascular Intensive Care Unit and Heart Failure Clinic, University of Iowa Hospitals and College of Medicine, Iowa City, IA 52242, USA.

Trends in Cardiovascular Medicine

|January 18, 2011

Summary

Digitalis glycosides, used for heart failure, possess autonomic actions. They may act as neural sensitizing agents, impacting neurohumoral excitation in heart failure patients.

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Area of Science:

Cardiology
Neuroscience
Pharmacology

Background:

Heart failure is characterized by neurohumoral excitation.
Abnormalities in baroreflex control contribute significantly to this excitation.
Digitalis glycosides are established inotropic agents for heart failure management.

Purpose of the Study:

To explore the autonomic actions of digitalis glycosides.
To investigate the role of digitalis glycosides as neural sensitizing agents in heart failure.

Main Methods:

Review of new experimental evidence.
Analysis of clinical data.

Main Results:

Digitalis glycosides exhibit significant autonomic actions.
Evidence suggests a major role for digitalis glycosides as neural sensitizing agents.

Conclusions:

Digitalis glycosides may have a broader therapeutic role in heart failure beyond inotropic effects.
Autonomic modulation by digitalis glycosides is a key factor in managing heart failure neurohumoral excitation.