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GMP-140, a receptor that mediates interactions of leukocytes with activated platelets and endothelium

R P McEver1

  • 1Department of Medicine, St. Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Trends in Cardiovascular Medicine
|January 18, 2011
PubMed

Insights

Platelet GMP-140 (granule membrane protein-140) moves to the cell surface upon activation, aiding neutrophil and monocyte adhesion. This molecule may be a target for blocking inflammation and injury in diseases.

Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • GMP-140 (granule membrane protein-140) is a glycoprotein in platelets and endothelium.
  • It resides in secretory granules and moves to the cell surface upon activation.

Purpose of the Study:

  • To investigate the role of GMP-140 in cell adhesion and inflammatory processes.
  • To explore GMP-140 as a potential therapeutic target for inflammatory disorders.

Main Methods:

  • The abstract does not specify methods.
  • Further study of GMP-140 structure and function is suggested.

Main Results:

  • GMP-140 promotes rapid adhesion of neutrophils and monocytes to activated endothelium.
  • It facilitates platelet-leukocyte interactions in inflammation and hemorrhage.
  • GMP-140 is implicated in inflammatory disorders like reperfusion injury.

Conclusions:

  • GMP-140 plays a key role in leukocyte adhesion and inflammatory responses.
  • Understanding GMP-140 may lead to novel therapeutic strategies for blocking leukocyte adhesion in diseases.

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