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Updated: Jun 5, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Intravascular stents.

G D Chapman¹, R S Gammon, R P Bauman

¹Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Trends in Cardiovascular Medicine

|January 18, 2011

Summary

This summary is machine-generated.

Intravascular stents improve outcomes after percutaneous transluminal coronary angioplasty (PTCA) by treating acute closure and reducing restenosis. This review covers ideal stent characteristics, ongoing trials, and future applications like drug delivery.

Related Experiment Videos

Last Updated: Jun 5, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Area of Science:

Cardiovascular Medicine
Biomaterials Science
Interventional Cardiology

Background:

Percutaneous transluminal coronary angioplasty (PTCA) faces limitations including acute arterial closure and restenosis.
Metallic stents have demonstrated effectiveness in clinical trials for managing acute closure and reducing restenosis rates in select patients.

Purpose of the Study:

To review the characteristics of an ideal intravascular stent.
To examine current clinical trials evaluating novel stent prototypes.
To discuss the future potential of stents in localized drug and gene therapy.

Main Methods:

Review of existing literature on intravascular stent development and clinical trials.
Analysis of data from human clinical trials involving metallic stents.
Exploration of emerging stent technologies, including radiopaque and bioabsorbable materials.

Main Results:

Metallic stents show efficacy in treating acute arterial closure post-PTCA.
Stents can lower restenosis rates in specific patient populations.
Developmental stents incorporate advanced materials and functionalities.

Conclusions:

Intravascular stents are crucial for overcoming PTCA limitations.
Ongoing research focuses on optimizing stent design and materials.
Stents hold promise as platforms for targeted therapeutic delivery.