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Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Genesis and "suicide" of eicosanoid biosynthetic enzymes
1Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Abstract:
Biologically active eicosanoids are substances that initiate, aggravate, or sustain thrombosis and inflammation. Prominent in this regard are thromboxane A(2), a potent coronary vasoconstrictor and platelet-aggregating factor and leukotriene B(4), a potent leukocyte chemotactic agent. Pharmacologic restraint of their formation may be beneficial. Recent research on the natural regulation of their formation recognizes the importance of two processes: the genesis of enzymes and proteins that amplify eicosanoid formation and the "suicide" inactivation that accompanies this formation. The balance of genesis-"suicide" of eicosanoid biosynthetic enzymes offers a new way to raise questions about the role of eicosanoids in cardiac disorders.
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