Related Experiment Videos
Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation
V A Holland1, P T Cagle, N T Windsor
1Rockwell-McKelvey Pulmonary Immunology Laboratory, Baylor College of Medicine, Houston, Texas.
Abstract:
The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.