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Updated: Jun 5, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
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Published on: July 7, 2023

POEMS Syndrome.

C R Debnath1, M R Debnath, G C Roy

  • 1Department of Hepatology, Mymensingh Medical College, Mymensingh, Bangladesh.

Mymensingh Medical Journal : MMJ
|January 18, 2011
PubMed
Summary
This summary is machine-generated.

This case study highlights POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes), a rare disorder. The patient presented with unique burning sensations, demonstrating the syndrome

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Last Updated: Jun 5, 2026

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05:19

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Area of Science:

  • Neurology
  • Hematology
  • Dermatology

Background:

  • POEMS syndrome is a rare multisystem disorder.
  • Characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.

Observation:

  • A 49-year-old male presented with a 2-year history of sensorimotor polyneuropathy, sclerodermic skin changes, erectile dysfunction, and hepatosplenomegaly.
  • The patient's primary and unusual complaint was a severe, body-wide burning sensation, leading to extensive prior medical consultations.

Findings:

  • Clinical evaluation confirmed the diagnosis of POEMS syndrome based on established criteria.
  • The patient exhibited a unique presentation dominated by severe burning neuropathy.

Implications:

  • This case underscores the diverse and sometimes atypical clinical manifestations of POEMS syndrome.
  • Highlights the importance of considering POEMS syndrome in patients with unexplained sensorimotor polyneuropathy and systemic symptoms.
  • Effective treatment with corticosteroids and melphalan was observed, suggesting therapeutic options for complex cases.