Study of anti-ischemic effect of afobazole in experimental myocardial infarction
S A Kryzhanovskyi1, A V Sorokina, V N Stolyaruck
1V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. SAK538@yandex.ru
Bulletin of Experimental Biology and Medicine
|January 18, 2011
Abstract:
Seven-day treatment of rats with experimental myocardial infarction with afobazole (5-ethoxy-2-[2-morpholino)-ethylthio] benzimidasole dihydrochloride) resulted in shrinkage of the ischemic damage area in the heart, stimulation of reparative processes in the myocardium, and prevention of postinfarction remodeling of the left ventricle. Anti-ischemic effect of afobazole in experimental myocardial infarction is presumably due to its interactions with σ(1) receptors.
