C-H oxidation by platinum group metal oxo or peroxo species
1Department of Chemistry, Yale University, New Haven, CT 06520, USA. meng.zhou@yale.edu
Chemical Society Reviews
|January 18, 2011
Abstract:
While C-H oxidation by ruthenium oxo compounds has been broadly applied in organic synthesis, examples of C-H oxidation by metal oxo complexes from the rest of the platinum group are still rare. We survey the preparation and reactivity of these late-transition metal oxo and peroxo complexes in this tutorial review.
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Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...