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Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
Published on: January 10, 2025
Cough hypersensitivity syndrome: a distinct clinical entity
A H Morice1, S Faruqi, C E Wright
1Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK.
Lung
|January 18, 2011
Summary
The Hull Airway Reflux Questionnaire (HARQ) effectively identifies cough hypersensitivity syndrome, a unified cause for chronic cough. This validated tool aids in diagnosing this common respiratory condition.
Area of Science:
- Pulmonology
- Clinical Diagnostics
- Psychometrics
Background:
- Chronic cough is often attributed to a single condition: cough hypersensitivity syndrome.
- A validated questionnaire is needed to identify and diagnose this syndrome.
Purpose of the Study:
- To describe the validation of the Hull Airway Reflux Questionnaire (HARQ).
- To establish HARQ as a diagnostic instrument for cough hypersensitivity syndrome.
Main Methods:
- Iterative development and validation of the 14-item HARQ.
- Administered HARQ to 185 chronic cough patients and 70 healthy volunteers.
- Assessed construct validity, criterion validity, repeatability, and responsiveness to treatment.
Main Results:
- HARQ demonstrated high sensitivity (94%) and specificity (95%) in distinguishing patients from controls (AUC 0.99).
- The questionnaire showed excellent internal consistency, repeatability, and responsiveness to treatment.
- Minimum clinically significant change was determined to be 16 points.
Conclusions:
- The HARQ is a valid, reproducible, and responsive diagnostic instrument.
- Supports the concept of chronic cough as a single entity: cough hypersensitivity syndrome.
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