Related Experiment Video
Updated: Jun 5, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary
Chueh-Chuan Yen1, Yen-Po Tsao, Paul Chih-Hsueh Chen
1Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. ccyen@vghtpe.gov.tw
Background And Objectives:
We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery.
Methods:
Expression patterns of PML and tumor protein 53 (TP53) of 132 cases of ESCC were evaluated by immunohistochemistry and correlated with clinicopathological parameters. The Cox proportional hazards model was used to determine the prognostic influence of clinicopathological factors on progression-free survival (PFS) and overall survival (OS).
Results:
Forty-two cases (31.82%) were classified as lost expression of PML, 25 (18.94%) as focally positive, and 65 (49.24%) as diffusely expressed. Sixty-three cases (47.73%) were classified as over-expression of TP53. High expression of TP53 and down-regulation of PML were often found in advanced disease; and, in together with high pathological staging, grading, and positive margin, were associated with poor survival. However, only tumor differentiation (P = 0.016), distant metastasis (P = 0.001), and PML expression (P = 0.001) could act as independent prognostic factors for PFS, and LN metastasis (P = 0.004), TP53 (P = 0.006), and PML expression (P = 0.029) were identified as independent prognostic factors for OS in multivariate analysis.
Conclusions:
Our study demonstrated PML protein as an independent prognostic marker for patients with ESCC receiving primary surgery.