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Effect of a fixed brimonidine-timolol combination on intraocular pressure after phacoemulsification
Nikolaos Pharmakakis1, Konstantinos Giannopoulos, Stavros Stasinos
1Department of Ophthalmology, University of Patras, Medical School, Patras, Greece.
Purpose:
To evaluate the effect of a fixed combination of brimonidine-timolol on intraocular pressure (IOP) after phacoemulsification cataract surgery.
Setting:
Department of Ophthalmology, Patras University Hospital, Patras, Greece.
Design:
Prospective randomized comparative case series.
Methods:
Patients scheduled for phacoemulsification were randomly assigned to 1 of 2 groups. The treatment group received 1 drop of brimonidine-timolol fixed combination immediately after surgery, and the control group received no treatment. The IOP was measured preoperatively and 6, 12, and 24 hours postoperatively.
Results:
The treatment group comprised 28 eyes and the control group, 30 eyes. The mean IOP increased by 0.14 mm Hg ± 3.88 (SD) (P = .88) in the treatment group and increased by 2.8 ± 5.01 mm Hg (P = .007) in the control group. Twelve hours after surgery, the mean IOP decreased by -0.57 ± 3.82 mm Hg (P = .49) in the treatment group and increased by 2.20 ± 4.56 mm Hg (P = .009) in the control group. Twenty-four hours after surgery, the mean IOP decreased by -1.57 ± 2.30 mm Hg (P=.012) in the treatment group and increased by 0.86 ± 4.21 mm Hg (P = .175) in the control group. The mean IOP change between the 2 study groups 6, 12, and 24 hours postoperatively was statistically significantly different (P = .015, P = .006, and P = .003; respectively).
Conclusion:
The fixed brimonidine-timolol combination effectively reduced IOP 6, 12, and 24 hours after phacoemulsification cataract surgery.
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