Jove
Visualize
Contact Us

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal Ultrasound Diagnosis of Unilateral Pulmonary Agenesis.

Journal of medical ultrasound·2024
Same author

Excess resource use and cost of drug-resistant infections for six key pathogens in Europe: a systematic review and Bayesian meta-analysis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2023
Same author

Early life corticosteroid overexposure: Epigenetic and fetal origins of adult diseases.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2023
Same author

Association of Patients' Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis.

Biomedicines·2022
Same author

Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2022
Same author

Ultrasonographic Diagnosis of Twin-to-Twin Transfusion Syndrome.

American journal of perinatology·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 5, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

[Endothelial microparticles in preeclampsia and eclampsia].

Eduardo Reyna-Villasmil1, Jorly Mejia-Montilla, Nadia Reyna-Villasmil

  • 1Servicio de Obstetricia y Ginecología - Maternidad Dr. Nerio Belloso, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela. sippenbauch@gmail.com

Medicina Clinica
|January 19, 2011
PubMed
Summary

Endothelial microparticle levels are elevated in women with preeclampsia and eclampsia compared to healthy pregnancies. These findings highlight potential biomarkers for these hypertensive disorders in pregnancy.

More Related Videos

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Research
  • Perinatal Medicine

Background:

  • Preeclampsia and eclampsia are severe hypertensive disorders of pregnancy.
  • Endothelial dysfunction is a key feature of these conditions.
  • Endothelial microparticles (EMPs) are emerging biomarkers of endothelial injury.

Purpose of the Study:

  • To compare endothelial microparticle levels in women with eclampsia, preeclampsia, and normotensive pregnancies.
  • To investigate the relationship between EMPs and the severity of hypertensive disorders in pregnancy.

Main Methods:

  • A comparative study involving 30 mild preeclampsia, 30 severe preeclampsia, 30 eclampsia patients, and 35 healthy pregnant controls.
  • Blood samples were collected pre-delivery and post-diagnosis for EMP determination.
  • Statistical analysis including linear regression was performed.

Main Results:

  • Significantly higher endothelial microparticle values were observed in patients with eclampsia and severe preeclampsia compared to controls.
  • Mild preeclampsia patients showed lower EMP values than severe cases but still higher than controls.
  • Uric acid, 24-hour proteinuria, transaminases, and platelet count were significant factors affecting EMP levels.

Conclusions:

  • Eclamptic and preeclamptic pregnant women exhibit elevated endothelial microparticle levels compared to normotensive women.
  • EMPs may serve as valuable indicators of endothelial dysfunction in hypertensive disorders of pregnancy.
  • Further research can explore EMPs as diagnostic or prognostic markers.