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Angiotensin and carotid body chemoreception in heart failure

Harold D Schultz1

  • 1Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA. hschultz@unmc.edu

Current Opinion in Pharmacology
|January 19, 2011
PubMed

Insights

The carotid body

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Neuroscience

Background:

  • The carotid body (CB) is crucial for respiratory and cardiovascular autonomic control.
  • CB chemoreceptor activity increases in chronic heart failure (CHF), worsening sympathetic hyperactivity.
  • A local angiotensin system within the CB influences its function in CHF and hypoxia.

Purpose of the Study:

  • To review recent findings on the role of the local renin-angiotensin system in carotid body (CB) function.
  • To focus on the impact of Angiotensin II (Ang II) and Angiotensin-(1-7) [Ang-(1-7)] on CB function in chronic heart failure (CHF).

Main Methods:

  • Literature review of recent studies on carotid body (CB) function.
  • Analysis of the role of local angiotensin (Ang) system metabolites in CB chemoreceptor activity.
  • Focus on Angiotensin II (Ang II) and Angiotensin-(1-7) [Ang-(1-7)] effects in chronic heart failure (CHF) models.

Main Results:

  • Angiotensin I (Ang I) metabolites exert significant effects within the carotid body (CB).
  • Angiotensin II (Ang II) and Angiotensin-(1-7) [Ang-(1-7)] modulate CB chemoreceptor activity.
  • These local angiotensin peptides influence CB function in chronic heart failure (CHF).

Conclusions:

  • The local renin-angiotensin system in the carotid body (CB) is a key regulator of its function.
  • Angiotensin II (Ang II) and Angiotensin-(1-7) [Ang-(1-7)] play critical roles in CB dysfunction in chronic heart failure (CHF).
  • Targeting the local CB angiotensin system may offer therapeutic strategies for CHF.

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