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Updated: Jun 5, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Fluoride content of water used to reconstitute infant formula
Julie E A Steinmetz1, E Angeles Martinez-Mier, James E Jones
1Department of Pediatric Dentistry, Riley Hospital for Children, Indiana University School of Dentistry, 702 Barnhill Drive, Indianapolis, IN 46202, USA. jeastein@iupui.edu
Objective:
To assess the fluoride content of water used to reconstitute infant formula by a Latino population living in the Indianapolis, Indiana, area.
Background:
Negligible as well as excessive fluoride can be detrimental to oral health. Estimates of fluoride intake and exposure for individuals may aid in the determination of their risk for developing dental fluorosis or caries.
Methods:
Interviews were conducted to determine brands of bottled water used to reconstitute infant formula. Identified brands were analyzed for fluoride concentration.
Results:
Of the 458 samples tested (from 20 brands), fluoride concentration ranged from 0.006 to 0.740 μg/mL. All brands but one had fluoride concentration less than 0.7 μg/mL, with 16 brands having less than 0.22 μg/mL. Most bottled waters analyzed in the study comply with the American Dental Association recommendation to prevent fluorosis. Comparisons made demonstrated that only waters targeted for infants and that are fluoridated do not comply with recent American Dental Association recommendations.
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