Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

R Cui ¹, Y Okada , S G Jang

⁰Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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January 19, 2011

View abstract on PubMed

Summary

This study identified a new genetic risk factor, SLC22A3, for distal colon cancer in Asians. Combining genetic and environmental factors like alcohol may double colorectal cancer risk.

Area Of Science

Genetics
Oncology
Epidemiology

Background

Colorectal cancer (CRC) incidence is rising, particularly in Japan.
Early detection of CRC improves patient outcomes.
Identifying epidemiological factors is crucial for CRC prevention and early detection.

Purpose Of The Study

To identify genetic loci associated with colorectal cancer risk.
To investigate CRC risk factors based on tumor location.
To understand the role of genetic variants in CRC etiology.

Main Methods

Genome-wide association study (GWAS) on 1583 Japanese CRC cases and 1898 controls.
Sub-analyses by tumor location.
Replication analyses with 4809 CRC cases and 2973 controls, including Korean subjects.

Main Results

A novel locus (rs7758229 in SLC22A3) associated with distal colon cancer was identified (p = 7.92 × 10⁻⁹).
Replication confirmed associations between CRC and SNPs on 8q24 (rs6983267, rs7837328).
Cumulative effects of three genetic factors and alcohol consumption approximately doubled CRC risk.

Conclusions

A novel susceptible locus in SLC22A3 contributes to distal colon cancer risk in Asians.
Findings enhance understanding of common genetic variants in CRC etiology.
Further research into genetic and environmental interactions for CRC is warranted.

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