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Published on: March 10, 2021
Visual extinction in relation to visuospatial neglect after right-hemispheric stroke: quantitative assessment and
S Vossel1, P Eschenbeck, P H Weiss
1Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Leo-Brandt-Str 5, 52425 Jülich, Germany. s.vossel@fz-juelich.de
Journal of Neurology, Neurosurgery, and Psychiatry
|January 19, 2011
Summary
Visual neglect and extinction are distinct neurological syndromes following right-hemisphere stroke. Research shows they can occur independently and are linked to different brain lesion locations.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Visual neglect and extinction are common neurological syndromes after right-hemispheric brain damage.
- The association and shared neural substrates between these two syndromes remain debated.
Purpose of the Study:
- To investigate the relationship between visual neglect and extinction.
- To identify distinct neural substrates associated with each syndrome.
Main Methods:
- A novel computerized diagnostic test was used to assess extinction and neglect in 56 right-hemispheric stroke patients.
- Detection probabilities were measured under uni- and bilateral stimulation conditions.
- Statistical lesion-symptom mapping was performed on identified patient clusters.
Main Results:
- Extinction and neglect co-occurred in some patients but also appeared independently, indicating a double dissociation.
- Lesions in the right inferior parietal cortex correlated with visual extinction severity.
- Visuospatial neglect was linked to fronto-parietal damage, with specific areas affecting different tasks.
Conclusions:
- Extinction and neglect are dissociable syndromes in right-hemispheric stroke patients.
- These syndromes can be linked to distinct neural substrates.
- Extinction is specifically associated with focal damage in the right inferior parietal cortex.
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