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Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding
Gordon H Sun1, Brian M Harmych, J Matthew Dickson
1Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center, Ohio, USA. Gordon.H.Sun@gmail.com
Insights
Post-tonsillectomy bleeding (PTB) in children may indicate underlying coagulopathy. Activated partial thromboplastin time and platelet function assays are key diagnostic tools for identifying these occult bleeding disorders.
Area of Science:
- Pediatric Otolaryngology
- Pediatric Hematology
- Clinical Diagnostics
Background:
- Post-tonsillectomy bleeding (PTB) is a common complication in pediatric patients.
- Identifying underlying coagulopathies is crucial for effective management of PTB.
- Occult bleeding disorders may present atypically, complicating diagnosis.
Purpose of the Study:
- To determine the prevalence of coagulopathy in children with PTB.
- To identify risk factors associated with occult coagulopathy in this population.
Main Methods:
- Retrospective medical chart review at a tertiary-care pediatric hospital.
- Analysis of 182 pediatric patients presenting with PTB between January and December 2007.
- Inclusion of demographics, laboratory results (prothrombin time, activated partial thromboplastin time, platelet function assays), and clinical outcomes.
Main Results:
- Four percent (8 of 182) of children were diagnosed with a coagulopathy.
- Coagulopathic children showed significantly higher activated partial thromboplastin time and abnormal platelet function assays (PFAs).
- No significant differences in age, sex, race, or time post-tonsillectomy were found between groups.
Conclusions:
- Activated partial thromboplastin time and PFA studies, along with hematology consultations, aid in diagnosing occult coagulopathies in children with PTB.
- The definition of PTB should encompass any history of oral bleeding, irrespective of physical examination findings.
Objective:
To determine the prevalence of coagulopathy among children presenting with posttonsillectomy bleeding (PTB) and describe risk factors that could indicate the presence of occult coagulopathy.
Design:
Retrospective medical chart review.
Setting:
Tertiary-care pediatric hospital.
Patients:
The study population comprised 182 patients presenting with PTB from January to December 2007.
Main Outcome Measures:
Demographics, laboratory studies, type of intervention, transfusion status, need for hematology consultation, type of coagulopathy, and disposition were recorded.
Results:
There were 216 emergency department (ED) encounters for PTB. The mean age of the patients was 8.4 years, and 56% were male and 79% were white. Patients presented on mean postoperative day 5.9. Of the 182 children, 34 (19%) presented with abnormally elevated prothrombin time, activated partial thromboplastin time, or platelet function assays (PFAs) for both adenosine diphosphate and epinephrine. Eight patients (4%) ultimately were diagnosed as having a coagulopathy. Differences in mean age (P = .23), sex (P = .47), race (P = .76), number of days posttonsillectomy (P = .34), and higher ED visit frequency (P = .06) between the coagulopathic and noncoagulopathic children were not statistically significant. Coagulopathic children had significantly higher mean activated partial thromboplastin time (P < .001), PFA for adenosine diphosphate (P < .001), and PFA for epinephrine (P = .001). Of the 8 coagulopathic children, 3 (38%) presented with a history of oral bleeding and a normal physical examination.
Conclusions:
In children presenting with PTB, activated partial thromboplastin time and PFA studies and hematology consultations are helpful in identifying occult coagulopathies. The definition of PTB should be broadened to include children with any history of oral bleeding, regardless of examination findings.
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