Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare professionals' knowledge, attitudes, and practice with addressing sexual health among people living with inflammatory bowel disease: A UK cross-sectional survey.

Inflammatory bowel diseases·2026
Same author

ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment.

Journal of Crohn's & colitis·2026
Same author

ECCO Guidelines on Therapeutics in Ulcerative Colitis: Surgical Treatment.

Journal of Crohn's & colitis·2026
Same author

Mirikizumab is associated with rapid and sustained improvements in novel measures of bowel urgency in moderately-to-severely active ulcerative colitis: 28-week results from the LUCENT-URGE trial.

Journal of Crohn's & colitis·2026
Same author

IDEA-FAST clinical study protocol: Identifying digital end-points of fatigue, sleep quality and daytime sleepiness in N = 2000.

Digital health·2026
Same author

Reply to comments on pregnancy and inflammatory bowel diseases.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2026

Related Experiment Video

Updated: Jun 5, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Acute severe ulcerative colitis: timing is everything.

Stephen R Gulliford1, Jimmy K Limdi

  • 1Pennine Acute Hospitals NHS Trust, Greater Manchester BL9 7TD, UK.

Postgraduate Medical Journal
|January 19, 2011
PubMed
Summary

Acute severe ulcerative colitis requires prompt emergency care. Initial corticosteroid therapy fails in a third of patients, necessitating timely decisions on rescue treatments like ciclosporin or infliximab, or surgery.

Area of Science:

  • Gastroenterology and Internal Medicine
  • Inflammatory Bowel Disease (IBD) Research
  • Emergency Medicine

Background:

  • Idiopathic inflammatory bowel diseases (IBD), primarily Crohn disease and ulcerative colitis, affect around 240,000 people in the UK.
  • Acute severe ulcerative colitis (ASUC) is a critical medical emergency requiring immediate and effective management.
  • ASUC necessitates specialist care, but emergency physicians must understand core management principles for optimal patient outcomes.

Purpose of the Study:

  • To outline the essential principles for managing acute severe ulcerative colitis in an emergency setting.
  • To review the evidence base for treatment choices in ASUC.
  • To guide emergency physicians in making critical decisions regarding rescue therapy or surgery.

Main Methods:

Related Experiment Videos

Last Updated: Jun 5, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

  • Review of current evidence and established guidelines for the management of acute severe ulcerative colitis.
  • Analysis of treatment pathways, including initial corticosteroid therapy and subsequent options.
  • Discussion of the roles of rescue therapies (ciclosporin, infliximab) and surgical intervention.

Main Results:

  • Corticosteroids are the primary initial treatment for ASUC.
  • Approximately one-third of patients do not respond to corticosteroids.
  • Timely and informed decisions are crucial for selecting appropriate rescue therapy or surgical intervention for non-responders.

Conclusions:

  • Effective management of ASUC in the emergency department can significantly reduce morbidity and mortality.
  • Emergency physicians play a vital role in the initial assessment and management of ASUC.
  • Evidence-based decision-making is key to optimizing outcomes for patients with ASUC, balancing treatment efficacy with patient safety.