Related Experiment Videos

Malnutrition and inflammation determine prognosis of patients with CRS type 4

Imari Mimura1, Hiroshi Nishi, Takahiro Nishi

  • 1Division of Nephrology, Department of Medicine, Mitsui Memorial Hospital, Tokyo, Japan. imimura-tky@umin.ac.jp

Blood Purification
|January 19, 2011
PubMed

Insights

Malnutrition and inflammation predict poor survival in new hemodialysis (HD) patients with ischemic heart disease. Lower serum albumin and higher C-reactive protein levels are associated with increased mortality risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Uremic patients frequently develop ischemic heart disease before initiating hemodialysis (HD).
  • Chronic cardiorenal syndrome is recognized in predialysis patients, but prognostic factors in incident HD patients are poorly understood.

Purpose of the Study:

  • To identify prognostic factors for mortality in incident hemodialysis patients with cardiorenal syndrome type 4 (chronic cardiorenal syndrome).

Main Methods:

  • Retrospective analysis of 87 incident HD patients diagnosed with cardiorenal syndrome type 4 between 1984 and 2003.
  • Examination of survival and risk factors for mortality.

Main Results:

  • The 5-year survival rate was approximately 75%, with 25 deaths observed.
  • Lower serum albumin levels (p=0.03) and higher serum C-reactive protein levels (p=0.02) were significantly associated with increased all-cause and adjusted mortality.

Conclusions:

  • Malnutrition (indicated by low albumin) and inflammation (indicated by high C-reactive protein) are significant predictors of poor survival in incident HD patients with a history of ischemic heart disease.
Abstract

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...