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Microinflammation in hemodialysis patients is associated with increased CD14CD16(+) pro-inflammatory monocytes:

Hye Won Kim1, Ha-Na Yang, Myung Gyu Kim

  • 1Division of Nephrology, Department of Internal Medicine, Korea University Medical College, Seoul, Korea.

Blood Purification
|January 19, 2011
PubMed
Abstract

Insights

Pro-inflammatory monocytes increase inflammation in hemodialysis (HD) patients. On-line hemodiafiltration (HDF) reduces these monocytes and inflammation, suggesting a therapeutic benefit.

Area of Science:

  • Immunology
  • Nephrology

Background:

  • Increased pro-inflammatory CD14(+)CD16(+) monocytes are implicated in hemodialysis (HD) patient inflammation.
  • Understanding this monocyte subset's role is crucial for managing HD-related inflammatory conditions.

Purpose of the Study:

  • To investigate the contribution of pro-inflammatory monocytes to inflammation in HD patients.
  • To assess the impact of on-line hemodiafiltration (HDF) on these monocytes and associated inflammation.

Main Methods:

  • Flow cytometry was used to detect monocyte populations in HD patients, on-line HDF patients, and healthy controls.
  • Plasma cytokine levels and cytokine mRNA expression were measured.

Main Results:

  • HD patients exhibited elevated pro-inflammatory monocytes, plasma cytokines, and cytokine mRNA.
  • Pro-inflammatory monocytes were identified as a primary source of tumor necrosis factor-α.
  • On-line HDF treatment led to significant reductions in pro-inflammatory monocytes, plasma cytokines, and cytokine mRNA.

Conclusions:

  • Elevated pro-inflammatory monocytes likely drive inflammation in hemodialysis patients.
  • On-line HDF may exert beneficial effects by modulating the inflammatory response through reduced pro-inflammatory monocytes.

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