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Updated: Jun 5, 2026

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
Published on: February 8, 2022
Circuit start during continuous renal replacement therapy in vasopressor-dependent patients: the impact of a slow
In Byung Kim1, Nigel Fealy, Ian Baldwin
1Department of Intensive Care Medicine, Austin Hospital, Melbourne, Vic., Australia.
Background And Aims:
In vasopressor-dependent patients, we evaluated the impact of a slow blood flow protocol on hypotension when starting continuous renal replacement therapy (CRRT).
Methods:
Retrospective observational study in tertiary ICU of a slow blood flow protocol at the start of CRRT circuits.
Results:
205 circuits in 52 patients were studied. No significant changes in mean arterial pressure (MAP) and norepinephrine dose were found. Only 16 circuit starts in 13 patients were associated with a decrease in MAP >20%. In 23 filters and 11 patients, norepinephrine dose was >50 μg/min at baseline and also did not change significantly. There were no cardiac arrests or ventricular arrhythmias and CRRT was not discontinued because of hypotension.
Conclusions:
Implementation of a CRRT slow blood flow protocol in vasopressor-dependent patients enabled the initiation of CRRT circuits with limited hemodynamic consequences and no cardiac arrest or ventricular arrhythmia.
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