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Treatment of psychogenic polydipsia with acetazolamide: a report of 5 cases
Shunsuke Takagi1, Yutaka Watanabe, Takefumi Imaoka
1Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan. stakagi@ncnp.go.jp
Objective:
Psychogenic polydipsia occurs frequently in patients with chronic psychiatric illness and is often unmanageable. We herein report 5 patients in whom acetazolamide was trialed for this symptom.
Methods:
We encountered a case in which polydipsia improved with incidental administration of acetazolamide. We then used this treatment for 4 additional cases of treatment-resistant psychogenic polydipsia, some of which were accompanied by hyponatremia.
Results:
Acetazolamide improved polydipsia and/or hyponatremia in 4 of the 5 cases. This treatment was well tolerated and allowed 3 of the patients to permanently leave isolation.
Conclusion:
Acetazolamide appears to have a beneficial effect in psychogenic polydipsia.
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