Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mechanisms of HIV Latency in Hematopoietic Progenitors: GFI1 as a Key Regulator.

bioRxiv : the preprint server for biology·2026

Same author

Bacterial Meningitis Epidemiology in Burkina Faso and Niger - High-Risk Countries in the Meningitis Belt of Sub-Saharan Africa, 2015-2023.

The Journal of infectious diseases·2026

Same author

Use of the GSK MenACWY-CRM/MenB-4C Pentavalent Meningococcal Vaccine Among Persons Aged ≥10 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2025.

MMWR. Morbidity and mortality weekly report·2026

Same author

Inferring differential dynamics from multi-lineage, multi-omic, and multi-sample single-cell data with MultiVeloVAE.

Nature communications·2025

Same author

Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024.

The Journal of infection·2025

Same author

The epidemiology of bacterial meningitis in the United States during 2008-2023: an analysis of active, laboratory, population-based, multistate surveillance data.

Lancet regional health. Americas·2025

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

Hematopoietic stem/precursor cells as HIV reservoirs.

Lucy A McNamara¹, Kathleen L Collins

¹Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Current Opinion in HIV and AIDS

|January 19, 2011

Summary

Hematopoietic progenitor cells, including CD34+ bone marrow cells, may create persistent HIV reservoirs. Eradicating HIV requires targeting these additional viral reservoirs beyond CD4+ T cells.

More Related Videos

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

Area of Science:

Immunology
Virology
Hematology

Background:

Latent human immunodeficiency virus type 1 (HIV-1) infection in CD4+ T cells is a known contributor to viral persistence.
Emerging evidence indicates the existence of additional viral reservoirs beyond CD4+ T cells.

Purpose of the Study:

To review recent data on the role of hematopoietic progenitor cells (HPCs) in creating persistent HIV reservoirs.
To explore the potential of HPCs as a significant reservoir for HIV in vivo.

Main Methods:

Review of recent scientific literature and studies.
Focus on in vitro and in vivo infection models of HPCs.
Analysis of data from HIV-positive individuals on highly active antiretroviral therapy (HAART).

Main Results:

Certain HPCs, including multipotent hematopoietic progenitor cells and mast cell progenitors, can be infected by HIV.
CD34+ bone marrow cells have been identified as harboring latent HIV provirus in individuals with undetectable viral loads on HAART.
Latent infection of long-lived HPCs, particularly hematopoietic stem cells, presents a substantial barrier to HIV eradication.

Conclusions:

Eliminating HIV infection necessitates purging all viral reservoirs, including those within HPCs.
Multipotent hematopoietic progenitor cells and potentially mast cells represent significant HIV reservoirs.
Further research is required to identify specific CD34+ cell types infected in vivo and their contribution to residual viremia.