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Updated: Jun 5, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Anterior chamber angle imaging with optical coherence tomography.

C K-S Leung¹, R N Weinreb

¹Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Hong Kong, PR China. tlims00@hotmail.com

Eye (London, England)

|January 19, 2011

Summary

Optical coherence tomography (OCT) advancements enable detailed anterior chamber angle analysis for detecting angle closure. This technology improves visualization of key structures, aiding in understanding primary angle closure pathophysiology.

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Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography (OCT) technology has advanced significantly, transitioning from time-domain to spectral-domain and swept-source OCT.
OCT is crucial for assessing the anterior chamber angle and diagnosing angle closure glaucoma.

Purpose of the Study:

To summarize the evolution of OCT technology for anterior chamber angle measurement.
To review the applications of OCT in detecting angle closure.
To investigate the pathophysiology of primary angle closure using OCT.

Main Methods:

Utilizing spectral-domain and swept-source OCT for high-resolution imaging.
Employing 360° high-speed scanning for comprehensive angle evaluation.
Applying three-dimensional reconstruction for enhanced visualization of ocular structures.

Main Results:

Improved image resolution and scan speed allow detailed analysis of the anterior chamber angle.
Detailed examination of Schwalbe's line, Schlemm's canal, and scleral spur is now possible.
3D reconstruction enhances visualization of iris profiles and angle configurations.

Conclusions:

OCT is a vital tool for precise anterior chamber angle measurement and angle closure detection.
Advancements in OCT facilitate a deeper understanding of primary angle closure pathophysiology.
OCT's capabilities support comprehensive ophthalmic diagnostics and research.