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Updated: Jun 5, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
The role of the marrow microenvironment in hematopoietic stem cell transplantation
Aravind Ramakrishnan1, Beverly J Torok-Storb
1Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA.
Abstract:
The success of hematopoietic stem cell transplantation depends on the engraftment of pluripotent hematopoietic stem cells and the regulated proliferation and maturation of committed progenitor cells. It is generally agreed that these processes cannot occur without an appropriate milieu provided by a competent marrow microenvironment (ME). The ME is composed of both non-hematopoietic and hematopoietic stem cell derived cells and consequently is chimeric following allogeneic stem cell transplantation, containing recipient stromal cells and donor macrophages.
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